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As indicated, the major function of carnitine is to facilitate the transport of long-chain fatty acids (as fatty acylcarnitines) into the matrix of the mitochondria where the carnitine is subsequently exchanged for coenzyme A
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4.2 Metabolic reprogramming and the Warburg effect To compensate for impaired mitochondrial oxidative phosphorylation, tumor cells under ID conditions often shift to glycolysis for energy production, known as the Warburg effect (60)
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